@RogerPodacter said in abnormal noise when changing direction:

M566 X1000.00 Y1000.00 Z6.00 E300

You may want to raise your Z and E jerk values. 6mm/min is very slow and could be limiting your XY movement in unexpected ways especially if you have mesh compensation active. Same can be said for a too low E jerk value. A circle is made up of many small segments, and with a low jerk value the extruder may be trying to halt at each segment connection. Try increasing your E jerk to 1000, 2000, or even 3000. And increase your Z jerk to at least 60.