Maybe this is a bit unfair as I just tested cura right now for the first time (because of this thread) coming from s3d.
Parts layout is not very nice. I could not find any way to drop the part to the bed and had to resort to rotating and translating manually. This is way to clumsy. A basic drop face to bed needs to be implemented. Auto arrange placed parts outside the build volume
In the gcode preview I accidentally moved a model which wiped out the gcode I was reviewing.
No manual supports (yes I knew that, this is why I really didn't bother with it until today), and I do not se that i have any additional control over supports to make up for it. I use manual supports in 90% of my models (Most of the rest need no supports). I had to go hunting in the menus to actually get any semblance of controls to be visible. The usual problem I use manual support to solve is that I have parts with gaps that are too cramped to be able to extract supports from but can be bridged or can tolerate a little drooping, while I have other areas that needs the support. Hence the lack of control of the support is pretty much a dealbreaker.
I could not find any way to save the print settings changes I did as a profile. I guess there is a way, but it is not obvious. Clicking the create button in manage materials (which is where I thought it would be) does not appear to do anything.