There are 7 sets of step/dir/enable for external drivers on the expansion (5) and LCD_CONN (2) headers on the Duet. We have an expansion breakout board specifically designed to interface with large external drivers :
https://www.duet3d.com/Expansion_Breakout
External drivers that do not need 5V logic will work connected directly to the Duet.
The information is available here on the wiki:
https://duet3d.com/wiki/Using_external_drivers