@droftarts
Great! It's good to know the Duet 2 will handle it on the firmware side. I'd like to keep everything cooled passively since it'll be in a dusty environment, so external driver seems like the way to go. I know TB6600 and DM542's handle that just fine.
It looks like every "big" stepper driver wants 5v, and most of what I can find about 3.3v is that they sometimes work, but it's not necessarily reliable. The expansion breakout board seems to take care of 5v signaling by connecting DIR +, ENA +, and STEP + all together to +5v, with the negative pins on their respective pins. Assuming I'm understanding that correctly, I don't mind having to buy it to make everything work easily.