@IGEN said in No Response from Duet Maestro out of the box:
Could that have caused irreparable damage?
Nothing is irrepairable although most things on the board does take some effort to repair.
Its hard to say anything about the long term viability after a short, but given the supply was an USB port odds are it dealt with the surge, and if it didn't it would "just" be the 3.3v regulator to repair down the line which isn't too bad.