@Cj110109 Hello, Chris. As far as electronics setup goes, I don't really think there are any major nuggets I can give you, though I'd be happy to address any specific question. Once you abandon the original Creatbot toolboard abomination, your choices really aren't limited in any way. By which I mean, it no longer matters--electronically--that you are building an F430. As far as firmware and board ability go, you're just building a large, chamber-heated printer, so any resources towards that end will be valid for you. I originally went Duet 2, but very quickly switched to a Duet 3. If you're going the Klipper route, as you mention, there are plenty of resources out there for setup with that. My own experience is with the Duet ecosystem, and that's primarily what you'll find discussion of on these forums. You say you already have a mainboard; I would suggest making a list of all the connections you need, and then going through one by one and learning how to connect them to your board. There is variation out there on mainboard specs; your best bet is probably to find a forum that has a lot of activity relating to yours, because you can't assume that voltage/current tolerances, pull-up/pull-down state, etc. on one board's port will be the same as another's.
In relation to your project on a non-electrical note; I would never discourage someone from a project like this if it's something they just want to do for enjoyment or it's the resource they have. However, I would just warn you; after many chamber temperature cycles between ~95C and ambient over the last several years, the welds in my F430's box frame have cracked in places, and splits are evident through the paint as sheetmetal starts moving around. With certain motions it makes a clicking sound from something moving in the frame itself.
So, it does the job I modified if for; it prints large, good quality polycarbonate prints without warping/delamination. However, it wasn't originally designed for it, and the process seems to be beating it to death slowly. I could fire up the TIG and patch it up, but I'd still be left with a sheetmetal box with limited potential. I'm working on the CAD for a new high-temp machine, and after serving as the bootstrapper starting point for it, this one is going to end up retired.