I've got an E3D 2-wire PT100 sensor that I use in a 4-wire configuration. Maybe it's just be, but I constantly found the cartridge to wire connector a weak link. I'd get endless heater error despite all my efforts at strain relief. It all went away after I changed the connectors to some very secure RC ones.
So my configuration is as follows - 4 wires from PT100 daughter board (I've used twisted pairs in a shielded LAN cable), soldered together by pairs at the cartridge connector. Works really well. Just make sure you don't run any high-current wires (like extruder heater ones) completely parallel with the signal wires. In my case, having the wires twisted and in a shielded sheath mitigates that.