Titan with a 1.8 stepper should be in the 400-420 step range and double that if using a 0.9 degree stepper motor with the 16x microstepping. I have a bondtech BMG clone extruder on my ender 3 with a 0.9 degree pancake stepper motor...my esteps after calibration are 846.90. Also your acceleration is very high for your extruder which could also be causing issues. I have the max speed and acceleration for my extruder at 3000.
M350 X16 Y16 Z16 E16 I1 ; Configure microstepping with interpolation
M92 X80.00 Y80.00 Z400.00 E846.90 ; Set steps per mm (gregs wade was 604 steps)
M566 X500.00 Y500.00 Z30.00 E600.00 ; Set maximum instantaneous speed changes (mm/min)
M203 X10800.00 Y9000.00 Z300.00 E3000.00 ; Set maximum speeds (mm/min)
M201 X1000.00 Y1000.00 Z500.00 E3000.00 ; Set accelerations (mm/s^2)
M906 X700.00 Y700.00 Z700.00 E960.00 I30 ; Set motor currents (mA) and motor idle factor in per cent
M84 S30
EDIT: I see you commented out those high speeds...I didn't see the semi-colons at first glance.